Portfolio companies

www.impulse-dynamics.com

Impulse Dynamics is dedicated to advancing the treatment of heart failure for patients and the healthcare providers who care for them. The company pioneered its proprietary CCM therapy, which uses the Optimizer technology platform to improve quality of life in heart failure patients. CCM therapy is delivered through the Optimizer system, which includes an IPG implanted in a minimally invasive procedure and approved for commercial use in the United States and 44 countries worldwide. More than 9,000 patients have received the therapy as part of clinical trials and real-world use, where it is proven to be safe and effective for heart failure patients with debilitating symptoms who otherwise have few effective options available to them.

Cara is developing integrated software and hardware solutions for guidance in TAVR procedures. The Company’s augmented imaging apps include Aortic Annulus Line Tracking, Conduction System Overlay, Device Depth and Tilt presentation, Coronary Alignment and Conduction Disturbances monitoring that are all superimposed on the fluoroscopic images in real time during the procedure. The Cara disposables are consumables designed to prevent conduction disturbances during TAVR. Cara is performing a clinical trial in leading sites in Europe and North America and is working on applications for additional interventional transcatheter structural heart procedures.

Alta is a simple-to-use, low-cost, seamless to install solution that allows on-demand remote collaboration between doctors, industry experts, allied health professionals and their patients. The Alta platform can connect to up to 8 digital data sources (including all imaging, monitors & mapping systems) and is designed for live clinical communication, collaboration, remote control, smart content generation and enables secure 24/7 access to Cath-labs and Operation Rooms.

The company develops proprietary platforms for personalized, convergent and adaptive therapies that promote quality of life and medical outcome achievements. Using biometric feedback loops with real time validation and personalized therapeutic action, CardioVerge improves the use of drug + device therapies and addresses transitional care needs through securitized remote diagnosis and monitoring that enables proactive intervention.

Molecular Dynamics develops innovative imaging technologies and advanced clinical applications. The company’s whole-body functional imaging system, based on CZT technology, simultaneously improves image quality, scan time and patient dose. The scanner delivers better-than-PET quality images, with an attractive wide-band, multi-function imaging ability not possible with current PET scanners. The company aims to enable improved diagnosis, treatment-optimization and monitoring, resulting in more cost-effective treatments and better clinical outcomes.

Renal Dynamics (ReDy) is dedicated to treating hypertension with a single intervention, using its third-generation renal denervation system. ReDy’s proprietary solution uses the SmartRF algorithm to optimize bipolar and unipolar energy delivery and to confirm lesion formation. The system uses an advanced product design, intended to improve usability by the operator, shorten procedure time and improve patient comfort. The ReDy system has obtained CE mark and is currently being validated in clinical trials.

OncoD is an early-stage company seeking to improve the treatment of cancer by simplifying image-guided solid-tumor ablation procedures. OncoD is currently developing a set of interventional radiology imaging tools which aim to improve clinical outcomes and shorten procedure time through hyper-reality visualization, real-time accurate monitoring of treatment effects and patient-specific pre-planning and procedure guidance. These will provide high-definition mapping and navigation capabilities outside of the imaging suite and without radiating computed tomography (CT) or expensive magnetic resonance imaging (MRI) devices. The optimized graphic user interface will lower the dependency on physician experience and shorten learning curves, making the procedure and its clinical benefits widely available for cancer patients globally.

Lavita Technologies is an early-stage neuromodulation company, focused on development of the proprietary Nexion™ system for treatment of autoimmune inflammatory diseases caused by an overactive sympathetic nervous system. This breakthrough technology has a wide range of applications, including rheumatoid arthritis, inflammatory bowel disease, and metabolic disorders. The Nexion™ system utilizes a catheter-based percutaneous approach to deliver targeted and localized energy to modulate and reset nerve activities specific to the inflammation.

Public and acquired companies

EPD Solutions, now a Philips Company, developed the KODEX – EPD™ cardiac mapping and navigation system which utilizes electromagnetic technology to create real-time three-dimensional, high definition (3D-HD) images of a patient’s cardiac structures. Due to its design, the KODEX – EPD™ cardiac mapping and navigation system enables the operator to use their preferred mapping and ablation catheters, rather than sensor based catheters.

Spectrum Dynamics’ innovative imaging systems are based on its pioneering Broadview™ technology. Through personalized molecular imaging and unique image quality and resolution, Spectrum Dynamics’ scanning technology and accessories aim to revolutionize the field of nuclear medicine.
Exit: Merger

Part of the Johnson & Johnson group of companies, and with a portfolio of products including the CARTO advanced imaging system, Biosense-Webster specializes in the science of diagnosing and treating cardiac arrhythmia. Working in partnership with clinical experts, the company is a world leader in the development of technologies in arrhythmia care.
Exit: Merger

EPD Solutions, now a Philips Company, developed the KODEX – EPD™ cardiac mapping and navigation system which utilizes electromagnetic technology to create real-time three-dimensional, high definition (3D-HD) images of a patient’s cardiac structures. Due to its design, the KODEX – EPD™ cardiac mapping and navigation system enables the operator to use their preferred mapping and ablation catheters, rather than sensor based catheters.

Part of the Johnson & Johnson group of companies, and with a portfolio of products including the CARTO advanced imaging system, Biosense-Webster specializes in the science of diagnosing and treating cardiac arrhythmia. Working in partnership with clinical experts, the company is a world leader in the development of technologies in arrhythmia care.
Exit: Merger

Spectrum Dynamics’ innovative imaging systems are based on its pioneering Broadview™ technology. Through personalized molecular imaging and unique image quality and resolution, Spectrum Dynamics’ scanning technology and accessories aim to revolutionize the field of nuclear medicine.
Exit: Merger

Past companies

Robot-assisted solutions to meet the therapeutic needs of patients suffering from a variety of neurological conditions, including stroke, traumatic brain injury and spinal cord injury.

Focused on development and commercialization of minimally invasive treatment for type 2 diabetes.

Robot-assisted solutions to meet the therapeutic needs of patients suffering from a variety of neurological conditions, including stroke, traumatic brain injury and spinal cord injury.

Focused on development and commercialization of minimally invasive treatment for type 2 diabetes.

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